Lomustine Analogous Drug Structures for Intervention of Brain and Spinal Cord Tumors: The Benefit of In Silico Substructure Search and Analysis

Lomustine is a nitrosourea anticancer agent shown to be effective for treatment of childhood medulloblastoma. In silico substructure searches produced 17 novel nitrosourea agents analogous to lumustine and retaining activity for DNA alkylation and cytotoxic activity. The mean values for Log P, polar...

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Detalles Bibliográficos
Autor principal: Bartzatt, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652141/
https://www.ncbi.nlm.nih.gov/pubmed/23691318
http://dx.doi.org/10.1155/2013/360624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652141/
https://www.ncbi.nlm.nih.gov/pubmed/23691318
http://dx.doi.org/10.1155/2013/360624

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