Liposomes functionalized to overcome the blood–brain barrier and to target amyloid-β peptide: the chemical design affects the permeability across an in vitro model

PURPOSE: We investigated the ability of amyloid-β-targeting liposomes, decorated with an anti-transferrin receptor antibody, to cross the blood–brain barrier (BBB), comparing two antibody ligation techniques. METHODS: Fluorescent or radiolabeled liposomes composed of sphingomyelin/cholesterol and co...

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Detalles Bibliográficos
Autores principales: Salvati, Elisa, Re, Francesca, Sesana, Silvia, Cambianica, Ilaria, Sancini, Giulio, Masserini, Massimo, Gregori, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652512/
https://www.ncbi.nlm.nih.gov/pubmed/23674890
http://dx.doi.org/10.2147/IJN.S42783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652512/
https://www.ncbi.nlm.nih.gov/pubmed/23674890
http://dx.doi.org/10.2147/IJN.S42783

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