The Redox State of Cytochrome C Modulates Resistance to Methotrexate in Human MCF7 Breast Cancer Cells

BACKGROUND: Methotrexate is a chemotherapeutic agent used to treat a variety of cancers. However, the occurrence of resistance limits its effectiveness. Cytochrome c in its reduced state is less capable of triggering the apoptotic cascade. Thus, we set up to study the relationship among redox state...

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Detalles Bibliográficos
Autores principales: Barros, Susana, Mencia, Núria, Rodríguez, Laura, Oleaga, Carlota, Santos, Conceição, Noé, Verónique, Ciudad, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652835/
https://www.ncbi.nlm.nih.gov/pubmed/23675469
http://dx.doi.org/10.1371/journal.pone.0063276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652835/
https://www.ncbi.nlm.nih.gov/pubmed/23675469
http://dx.doi.org/10.1371/journal.pone.0063276

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