Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)–containing cargo from import receptors, and, under steady-state conditions, R...

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Detalles Bibliográficos
Autores principales: Snow, Chelsi J., Dar, Ashraf, Dutta, Anindya, Kehlenbach, Ralph H., Paschal, Bryce M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653351/
https://www.ncbi.nlm.nih.gov/pubmed/23649804
http://dx.doi.org/10.1083/jcb.201212117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653351/
https://www.ncbi.nlm.nih.gov/pubmed/23649804
http://dx.doi.org/10.1083/jcb.201212117

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