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Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport
The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)–containing cargo from import receptors, and, under steady-state conditions, R...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653351/ https://www.ncbi.nlm.nih.gov/pubmed/23649804 http://dx.doi.org/10.1083/jcb.201212117 |