Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Linkage-specific ubiquitination often leads to distinct cellular events. It has been difficult to establish definitively the requirement for a particular linkage in mammalian degradation pathways due to the inability to deplete endogenous ubiquitin while maintaining cell viability. The E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Xu, Ming, Scotti, Elena, Chen, Zhijian J., Tontonoz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653405/
https://www.ncbi.nlm.nih.gov/pubmed/23419260
http://dx.doi.org/10.1194/jlr.M035774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653405/
https://www.ncbi.nlm.nih.gov/pubmed/23419260
http://dx.doi.org/10.1194/jlr.M035774

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