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Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor
Linkage-specific ubiquitination often leads to distinct cellular events. It has been difficult to establish definitively the requirement for a particular linkage in mammalian degradation pathways due to the inability to deplete endogenous ubiquitin while maintaining cell viability. The E3 ubiquitin...
Autores principales: | Zhang, Li, Xu, Ming, Scotti, Elena, Chen, Zhijian J., Tontonoz, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Biochemistry and Molecular Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653405/ https://www.ncbi.nlm.nih.gov/pubmed/23419260 http://dx.doi.org/10.1194/jlr.M035774 |
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