Yohimbine Promotes Cardiac NE Release and Prevents LPS-Induced Cardiac Dysfunction via Blockade of Presynaptic α(2A)-Adrenergic Receptor

Myocardial depression is an important contributor to mortality in sepsis. We have recently demonstrated that α(2)-adrenoceptor (AR) antagonist, yohimbine (YHB), attenuates lipopolysaccharide (LPS)-induced myocardial depression. However, the mechanisms for this action of YHB are unclear. Here, we dem...

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Detalles Bibliográficos
Autores principales: Wang, Yiyang, Yu, Xiaohui, Wang, Faqiang, Wang, Yuan, Wang, Yanping, Li, Hongmei, Lv, Xiuxiu, Lu, Daxiang, Wang, Huadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653853/
https://www.ncbi.nlm.nih.gov/pubmed/23691077
http://dx.doi.org/10.1371/journal.pone.0063622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653853/
https://www.ncbi.nlm.nih.gov/pubmed/23691077
http://dx.doi.org/10.1371/journal.pone.0063622

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