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Yohimbine Promotes Cardiac NE Release and Prevents LPS-Induced Cardiac Dysfunction via Blockade of Presynaptic α(2A)-Adrenergic Receptor
Myocardial depression is an important contributor to mortality in sepsis. We have recently demonstrated that α(2)-adrenoceptor (AR) antagonist, yohimbine (YHB), attenuates lipopolysaccharide (LPS)-induced myocardial depression. However, the mechanisms for this action of YHB are unclear. Here, we dem...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653853/ https://www.ncbi.nlm.nih.gov/pubmed/23691077 http://dx.doi.org/10.1371/journal.pone.0063622 |