Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions. It is also a target for autoantibodies as specific antibodies have been demonstrated in the sera of patients affected by systemic autoimmune diseases. Following tra...

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Detalles Bibliográficos
Autores principales: Gugliesi, Francesca, Bawadekar, Mandar, De Andrea, Marco, Dell’Oste, Valentina, Caneparo, Valeria, Tincani, Angela, Gariglio, Marisa, Landolfo, Santo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653904/
https://www.ncbi.nlm.nih.gov/pubmed/23690979
http://dx.doi.org/10.1371/journal.pone.0063045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653904/
https://www.ncbi.nlm.nih.gov/pubmed/23690979
http://dx.doi.org/10.1371/journal.pone.0063045

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