Modelling Species Selectivity in Rat and Human Cytochrome P450 2D Enzymes

Updated models of the Rat Cytochrome P450 2D enzymes are produced based on the recent x-ray structures of the Human P450 2D6 enzyme both with and without a ligand bound. The differences in species selectivity between the epimers quinine and quinidine are rationalised using these models and the resul...

Descripción completa

Detalles Bibliográficos
Autores principales: Edmund, Grace H. C., Lewis, David F. V., Howlin, Brendan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653926/
https://www.ncbi.nlm.nih.gov/pubmed/23691026
http://dx.doi.org/10.1371/journal.pone.0063335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653926/
https://www.ncbi.nlm.nih.gov/pubmed/23691026
http://dx.doi.org/10.1371/journal.pone.0063335

Ejemplares similares