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Modelling Species Selectivity in Rat and Human Cytochrome P450 2D Enzymes
Updated models of the Rat Cytochrome P450 2D enzymes are produced based on the recent x-ray structures of the Human P450 2D6 enzyme both with and without a ligand bound. The differences in species selectivity between the epimers quinine and quinidine are rationalised using these models and the resul...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653926/ https://www.ncbi.nlm.nih.gov/pubmed/23691026 http://dx.doi.org/10.1371/journal.pone.0063335 |