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Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain

Calcium entry through CaV2.2 calcium channels clustered at the active zone (AZ) of the presynaptic nerve terminal gates synaptic vesicle (SV) fusion and the discharge of neurotransmitters, but the mechanism of channel scaffolding remains poorly understood. Recent studies have implicated the binding...

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Detalles Bibliográficos
Autores principales: Gardezi, Sabiha R., Li, Qi, Stanley, Elise F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654268/
https://www.ncbi.nlm.nih.gov/pubmed/23789098
http://dx.doi.org/10.1242/bio.20134267