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Towards the Total Synthesis of Pl-3: Preparation of the Eastern Fragment through a Diastereoselective SmI(2)-Mediated Reformatsky Reaction
The jatrophane diterpene Pl-3, isolated in 2003 from Euphorbia platyphyllos, is a structurally complex natural product with highly promising biological properties that include pronounced antiproliferative activity and the inhibition of the efflux-pump activity of multidrug resistance p-glycoprotein....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654569/ https://www.ncbi.nlm.nih.gov/pubmed/23687456 http://dx.doi.org/10.1002/ejoc.201300148 |