Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress

The mitochondria of slowly aging Mclk1(+/−) mutant mice produce high levels of reactive oxygen species (ROS). These animals display enhanced immune reactivity in response to lipopolysaccharide, Salmonella, and tumor-cell grafts, experience limited damage from these treatments and are partially prote...

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Detalles Bibliográficos
Autor principal: Hekimi, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654596/
https://www.ncbi.nlm.nih.gov/pubmed/23734326
http://dx.doi.org/10.4161/onci.23793
Descripción
Sumario:The mitochondria of slowly aging Mclk1(+/−) mutant mice produce high levels of reactive oxygen species (ROS). These animals display enhanced immune reactivity in response to lipopolysaccharide, Salmonella, and tumor-cell grafts, experience limited damage from these treatments and are partially protected from infection and tumorigenesis. We propose that the activation of the immune system by mitochondrial ROS reduces the rate of aging.

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