Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress

The mitochondria of slowly aging Mclk1(+/−) mutant mice produce high levels of reactive oxygen species (ROS). These animals display enhanced immune reactivity in response to lipopolysaccharide, Salmonella, and tumor-cell grafts, experience limited damage from these treatments and are partially prote...

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Detalles Bibliográficos
Autor principal: Hekimi, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654596/
https://www.ncbi.nlm.nih.gov/pubmed/23734326
http://dx.doi.org/10.4161/onci.23793
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author Hekimi, Siegfried
author_facet Hekimi, Siegfried
author_sort Hekimi, Siegfried
collection PubMed
description The mitochondria of slowly aging Mclk1(+/−) mutant mice produce high levels of reactive oxygen species (ROS). These animals display enhanced immune reactivity in response to lipopolysaccharide, Salmonella, and tumor-cell grafts, experience limited damage from these treatments and are partially protected from infection and tumorigenesis. We propose that the activation of the immune system by mitochondrial ROS reduces the rate of aging.
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spelling pubmed-36545962013-06-03 Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress Hekimi, Siegfried Oncoimmunology Author's View The mitochondria of slowly aging Mclk1(+/−) mutant mice produce high levels of reactive oxygen species (ROS). These animals display enhanced immune reactivity in response to lipopolysaccharide, Salmonella, and tumor-cell grafts, experience limited damage from these treatments and are partially protected from infection and tumorigenesis. We propose that the activation of the immune system by mitochondrial ROS reduces the rate of aging. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654596/ /pubmed/23734326 http://dx.doi.org/10.4161/onci.23793 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Hekimi, Siegfried
Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title_full Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title_fullStr Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title_full_unstemmed Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title_short Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
title_sort enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654596/
https://www.ncbi.nlm.nih.gov/pubmed/23734326
http://dx.doi.org/10.4161/onci.23793
work_keys_str_mv AT hekimisiegfried enhancedimmunityinslowlyagingmutantmicewithhighmitochondrialoxidativestress

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