Human perforin mutations and susceptibility to multiple primary cancers

Loss-of-function mutations in the gene coding for perforin (PRF1) markedly reduce the ability of cytotoxic T lymphocytes and natural killer cells to kill target cells, causing immunosuppression and impairing immune regulation. In humans, nearly half of the cases of type 2 familial hemophagocytic lym...

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Detalles Bibliográficos
Autores principales: Trapani, Joseph A., Thia, Kevin Y.T., Andrews, Miles, Davis, Ian D., Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G., Phillips, Wayne A., Voskoboinik, Ilia, Cebon, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654607/
https://www.ncbi.nlm.nih.gov/pubmed/23734337
http://dx.doi.org/10.4161/onci.24185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654607/
https://www.ncbi.nlm.nih.gov/pubmed/23734337
http://dx.doi.org/10.4161/onci.24185

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