Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size

Motivation: RNA-seq experiments produce digital counts of reads that are affected by both biological and technical variation. To distinguish the systematic changes in expression between conditions from noise, the counts are frequently modeled by the Negative Binomial distribution. However, in experi...

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Detalles Bibliográficos
Autores principales: Yu, Danni, Huber, Wolfgang, Vitek, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654711/
https://www.ncbi.nlm.nih.gov/pubmed/23589650
http://dx.doi.org/10.1093/bioinformatics/btt143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654711/
https://www.ncbi.nlm.nih.gov/pubmed/23589650
http://dx.doi.org/10.1093/bioinformatics/btt143

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