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Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size
Motivation: RNA-seq experiments produce digital counts of reads that are affected by both biological and technical variation. To distinguish the systematic changes in expression between conditions from noise, the counts are frequently modeled by the Negative Binomial distribution. However, in experi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654711/ https://www.ncbi.nlm.nih.gov/pubmed/23589650 http://dx.doi.org/10.1093/bioinformatics/btt143 |