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The Phenotype of the Cryptococcus-Specific CD4(+) Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal Meningitis

Background. Correlates of immune protection in patients with human immunodeficiency virus (HIV)–associated cryptococcal meningitis are poorly defined. A clearer understanding of these immune responses is essential to inform rational development of immunotherapies. Methods. Cryptococcal-specific peri...

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Detalles Bibliográficos
Autores principales: Jarvis, Joseph N., Casazza, Joseph P., Stone, Hunter H., Meintjes, Graeme, Lawn, Stephen D., Levitz, Stuart M., Harrison, Thomas S., Koup, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654748/
https://www.ncbi.nlm.nih.gov/pubmed/23493728
http://dx.doi.org/10.1093/infdis/jit099