Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs). With the aim of developing anti-cancer drugs targeting these nucleating complexe...

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Detalles Bibliográficos
Autores principales: Cala, Olivier, Remy, Marie-Hélène, Guillet, Valérie, Merdes, Andreas, Mourey, Lionel, Milon, Alain, Czaplicki, Georges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655011/
https://www.ncbi.nlm.nih.gov/pubmed/23691113
http://dx.doi.org/10.1371/journal.pone.0063908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655011/
https://www.ncbi.nlm.nih.gov/pubmed/23691113
http://dx.doi.org/10.1371/journal.pone.0063908

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