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Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment

BACKGROUND: Relapsed T-lineage acute lymphoblastic leukemia (T-ALL) has been an incurable disease. Recent reports showed that an L-arginine depleting enzyme, pegylated arginase (BCT-100) may be effective against T-ALL cells. On the other hand, studies including ours had shown the symbiosis of ALL bl...

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Detalles Bibliográficos
Autores principales: Kwong-Lam, Fung, Chi-Fung, Chan Godfrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655039/
https://www.ncbi.nlm.nih.gov/pubmed/23574711
http://dx.doi.org/10.1186/2162-3619-2-11