Fitness Costs of Synonymous Mutations in the rpsT Gene Can Be Compensated by Restoring mRNA Base Pairing

We previously reported that the distribution of fitness effects for non-synonymous and synonymous mutations in Salmonella typhimurium ribosomal proteins S20 and L1 are similar, suggesting that fitness constraints are present at the level of mRNA. Here we explore the hypothesis that synonymous mutati...

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Detalles Bibliográficos
Autores principales: Lind, Peter A., Andersson, Dan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655191/
https://www.ncbi.nlm.nih.gov/pubmed/23691039
http://dx.doi.org/10.1371/journal.pone.0063373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655191/
https://www.ncbi.nlm.nih.gov/pubmed/23691039
http://dx.doi.org/10.1371/journal.pone.0063373

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