Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy

Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human and mouse proteins required for HIV-1 entry and replication including CD4, CCR5 and cyclin T1. We overcame this limitation by constructing mice...

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Detalles Bibliográficos
Autores principales: Seay, Kieran, Qi, Xiaohua, Zheng, Jian Hua, Zhang, Cong, Chen, Ken, Dutta, Monica, Deneroff, Kathryn, Ochsenbauer, Christina, Kappes, John C., Littman, Dan R., Goldstein, Harris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655194/
https://www.ncbi.nlm.nih.gov/pubmed/23691059
http://dx.doi.org/10.1371/journal.pone.0063537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655194/
https://www.ncbi.nlm.nih.gov/pubmed/23691059
http://dx.doi.org/10.1371/journal.pone.0063537

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