Cargando…

Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy

Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human and mouse proteins required for HIV-1 entry and replication including CD4, CCR5 and cyclin T1. We overcame this limitation by constructing mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seay, Kieran, Qi, Xiaohua, Zheng, Jian Hua, Zhang, Cong, Chen, Ken, Dutta, Monica, Deneroff, Kathryn, Ochsenbauer, Christina, Kappes, John C., Littman, Dan R., Goldstein, Harris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655194/ https://www.ncbi.nlm.nih.gov/pubmed/23691059 http://dx.doi.org/10.1371/journal.pone.0063537

Ejemplares similares

Detection of HIV-1 Neutralizing Antibodies in a Human CD4(+)/CXCR4(+)/CCR5(+) T-Lymphoblastoid Cell Assay System
por: McLinden, Robert J., et al.
Publicado: (2013)

Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages
por: Shen, Ruizhong, et al.
Publicado: (2011)

Progress Toward a Human CD4/CCR5 Transgenic Rat Model for De Novo Infection by Human Immunodeficiency Virus Type 1
por: Keppler, Oliver T., et al.
Publicado: (2002)

Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP
por: Yamano, Yoshihisa, et al.
Publicado: (2015)

Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses
por: Prévost, Jérémie, et al.
Publicado: (2018)

Efficient macrophage infection by phagocytosis of dying HIV-1 -infected CD4+T cells
por: Groot, Fedde, et al.
Publicado: (2011)

The plasticity of HTLV-1 infected CD4+CD25+CCR4+ T-cells through HTLV-1 tax in HAM/TSP
por: Araya, Natsumi, et al.
Publicado: (2011)

The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria
por: Yoder, Alyson C., et al.
Publicado: (2017)

57 Increased Frequency of CD4+ CCR4+ CCR9+ Cells in Patients With Allergic Conjunctivitis
por: Alonso-Sánchez, Miguel E., et al.
Publicado: (2012)

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4(+)Cd25(+) Regulatory T Cells
por: Iellem, Andrea, et al.
Publicado: (2001)

Macrophage Infection via Selective Capture of HIV-1-Infected CD4(+) T Cells
por: Baxter, Amy E., et al.
Publicado: (2014)

CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients
por: Andalib, Alireza, et al.
Publicado: (2013)

Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7
por: Parrish, Nicholas F., et al.
Publicado: (2012)

CCR7 is required for the in vivo function of CD4(+) CD25(+) regulatory T cells
por: Schneider, Martin A., et al.
Publicado: (2007)

CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection
por: Anderson, Joseph, et al.
Publicado: (2005)

The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
por: Guan, Yongjun
Publicado: (2019)

HIV-1 Expressing the Envelopes of Transmitted/Founder or Control/Reference Viruses Have Similar Infection Patterns of CD4 T-Cells in Human Cervical Tissue Ex Vivo
por: Merbah, Melanie, et al.
Publicado: (2012)

Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice
por: Issuree, Priya D. A., et al.
Publicado: (2017)

Skewed Lung CCR4 to CCR6 CD4(+) T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function
por: Adegunsoye, Ayodeji, et al.
Publicado: (2016)

Study of CD27 and CCR4 Markers on Specific CD4(+) T-Cells as Immune Tools for Active and Latent Tuberculosis Management
por: Latorre, Irene, et al.
Publicado: (2019)

CD25+CCR4+ cells as a marker of HTLV-1-infected cells in peripheral blood
por: Kagdi, Huseini, et al.
Publicado: (2014)

Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4(+) T Cell Differentiation
por: Pezoldt, Joern, et al.
Publicado: (2016)

Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5
por: Roop, Jeremy I., et al.
Publicado: (2020)

An Imbalance between Frequency of CD4+CD25+FOXP3+ Regulatory T Cells and CCR4+ and CCR9+ Circulating Helper T Cells Is Associated with Active Perennial Allergic Conjunctivitis
por: Galicia-Carreón, J., et al.
Publicado: (2013)

Chemokine receptor CCR9 suppresses the differentiation of CD4(+)CD8αα(+) intraepithelial T cells in the gut
por: Li, Can, et al.
Publicado: (2022)

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
por: Singhania, Akul, et al.
Publicado: (2021)

Combining CSPG4-CAR and CD20-CCR for treatment of metastatic melanoma
por: Teppert, Karin, et al.
Publicado: (2023)

Genome editing of CCR5 by AsCpf1 renders CD4(+)T cells resistance to HIV-1 infection
por: Liu, Zhepeng, et al.
Publicado: (2020)

Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells
por: Couturier, Jacob, et al.
Publicado: (2019)

The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7
por: Hayasaka, Haruko, et al.
Publicado: (2015)

PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4(+) T cells
por: Yashiro, Takuya, et al.
Publicado: (2020)

IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5(+)CD4(+) T cells
por: Li, Yuhao, et al.
Publicado: (2023)

HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells
por: Lucera, Mark B., et al.
Publicado: (2017)

Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy
por: Brown, Matthew E., et al.
Publicado: (2022)

CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates
por: Laurén, Anna, et al.
Publicado: (2007)

Phenotypic and functional characterisation of CCR7(+ )and CCR7(- )CD4(+ )memory T cells homing to the joints in juvenile idiopathic arthritis
por: Gattorno, Marco, et al.
Publicado: (2005)

Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4(+) and CD8(+) T Cells
por: Neef, Tobias, et al.
Publicado: (2021)

Abnormally High Levels of Virus-Infected IFN-γ(+)CCR4(+)CD4(+)CD25(+) T Cells in a Retrovirus-Associated Neuroinflammatory Disorder
por: Yamano, Yoshihisa, et al.
Publicado: (2009)

Intestinal endothelial cells increase HIV infection and latency in resting and activated CD4 + T cells, particularly affecting CCR6 + CD4 + T cells
por: Eddy, Jessica, et al.
Publicado: (2023)

Identification of a Human Cyclin D1-Derived Peptide that Induces Human Cytotoxic CD4 T Cells
por: Dao, Tao, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_0n1nra3r9uitnfd6qrhnpgio9f