IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages

Chemokines, including MCP-1, are crucial to mounting an effective immune response due to their ability to recruit other immune cells. We show that sustained LPS or poly(I:C)-stimulated MCP-1 production requires an IFNβ-mediated feedback loop. Consistent with this, exogenous IFNβ was able to induce M...

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Detalles Bibliográficos
Autores principales: Pattison, Michael J., MacKenzie, Kirsty F., Elcombe, Suzanne E., Arthur, J. Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655261/
https://www.ncbi.nlm.nih.gov/pubmed/23542035
http://dx.doi.org/10.1016/j.febslet.2013.03.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655261/
https://www.ncbi.nlm.nih.gov/pubmed/23542035
http://dx.doi.org/10.1016/j.febslet.2013.03.025

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