nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge

Huntington's disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits. Excitotoxicity is thought to be involved in HD and several studies have indicated that NMDA receptor (NMDAR) overactivation ca...

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Detalles Bibliográficos
Autores principales: Canzoniero, Lorella M. T., Granzotto, Alberto, Turetsky, Dorothy M., Choi, Dennis W., Dugan, Laura L., Sensi, Stefano L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655281/
https://www.ncbi.nlm.nih.gov/pubmed/23720635
http://dx.doi.org/10.3389/fphys.2013.00112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655281/
https://www.ncbi.nlm.nih.gov/pubmed/23720635
http://dx.doi.org/10.3389/fphys.2013.00112

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