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Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes

BACKGROUND: Upon co-stimulation with CD3/CD28 antibodies, activated CD4 + T cells were found to lose their susceptibility to HIV-1 infection, exhibiting an induced resistant phenotype. This rather unexpected phenomenon has been repeatedly confirmed but the underlying cell and molecular mechanisms ar...

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Detalles Bibliográficos
Autores principales: Xu, Wen-Wen, Han, Miao-Jun, Chen, Dai, Chen, Ling, Guo, Yan, Willden, Andrew, Liu, Di-Qiu, Zhang, Hua-Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655860/
https://www.ncbi.nlm.nih.gov/pubmed/23635305
http://dx.doi.org/10.1186/1755-8794-6-15