Dual Regulation of Cadmium-Induced Apoptosis by mTORC1 through Selective Induction of IRE1 Branches in Unfolded Protein Response

Cadmium (Cd) causes generation of reactive oxygen species (ROS) that trigger renal tubular injury. We found that rapamycin, an inhibitor of mTORC1, attenuated Cd-induced apoptosis in renal tubular cells. Knockdown of Raptor, a positive regulator of mTORC1, also had the similar effect. However, rapam...

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Detalles Bibliográficos
Autores principales: Kato, Hironori, Katoh, Ryohei, Kitamura, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655991/
https://www.ncbi.nlm.nih.gov/pubmed/23696882
http://dx.doi.org/10.1371/journal.pone.0064344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655991/
https://www.ncbi.nlm.nih.gov/pubmed/23696882
http://dx.doi.org/10.1371/journal.pone.0064344

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