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Cytolytic granules supply Ca(2+) for their own exocytosis via NAADP and resident two-pore channels
When cytotoxic T-lymphocytes (CTLs) kill infected or cancerous cells they secrete cytolytic proteins (perforin and granzymes) into the target cell. These “death factors” are pre-stored in cytolytic granules within the CTL until an increase in the intracellular Ca(2+) drives granule exocytosis. Howev...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656026/ https://www.ncbi.nlm.nih.gov/pubmed/23713141 http://dx.doi.org/10.4161/cib.24175 |