In silico Driven Redesign of a Clinically Relevant Antibody for the Treatment of GD2 Positive Tumors

Ganglioside GD2 is a cell surface glycolipid that is highly expressed on cancer cells of neuroectodermal origin, including neuroblastoma, retinoblastoma, melanoma, sarcomas, brain tumors and small cell lung cancer. Monoclonal antibodies (MoAb) that target GD2 have shown clinical efficacy in the trea...

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Detalles Bibliográficos
Autores principales: Ahmed, Mahiuddin, Goldgur, Yehuda, Hu, Jian, Guo, Hong-Fen, Cheung, Nai-Kong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656052/
https://www.ncbi.nlm.nih.gov/pubmed/23696816
http://dx.doi.org/10.1371/journal.pone.0063359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656052/
https://www.ncbi.nlm.nih.gov/pubmed/23696816
http://dx.doi.org/10.1371/journal.pone.0063359

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