Saturated Very Long Chain Fatty Acids Are Required for the Production of Infectious Human Cytomegalovirus Progeny

Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To probe further the role of fatty acid metaboli...

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Detalles Bibliográficos
Autores principales: Koyuncu, Emre, Purdy, John G., Rabinowitz, Joshua D., Shenk, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656100/
https://www.ncbi.nlm.nih.gov/pubmed/23696731
http://dx.doi.org/10.1371/journal.ppat.1003333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656100/
https://www.ncbi.nlm.nih.gov/pubmed/23696731
http://dx.doi.org/10.1371/journal.ppat.1003333

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