Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115

Human serum albumin (HSA) and human parathyroid hormone (1-34) [PTH (1-34)] fusion protein [HSA/PTH (1-34)] is a promising long-acting form of PTH (1-34) for osteoporosis treatment. Secretory expression of intact HSA/PTH (1-34) in Pichia pastoris GS115 was accompanied by two degradation fragments, w...

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Detalles Bibliográficos
Autores principales: Wu, Min, Shen, Qi, Yang, Yong, Zhang, Sheng, Qu, Wen, Chen, Jing, Sun, Hongying, Chen, Shuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Biotechnology Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656227/
https://www.ncbi.nlm.nih.gov/pubmed/23529666
http://dx.doi.org/10.1007/s10295-013-1264-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656227/
https://www.ncbi.nlm.nih.gov/pubmed/23529666
http://dx.doi.org/10.1007/s10295-013-1264-8

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