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Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115
Human serum albumin (HSA) and human parathyroid hormone (1-34) [PTH (1-34)] fusion protein [HSA/PTH (1-34)] is a promising long-acting form of PTH (1-34) for osteoporosis treatment. Secretory expression of intact HSA/PTH (1-34) in Pichia pastoris GS115 was accompanied by two degradation fragments, w...
Autores principales: | Wu, Min, Shen, Qi, Yang, Yong, Zhang, Sheng, Qu, Wen, Chen, Jing, Sun, Hongying, Chen, Shuqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656227/ https://www.ncbi.nlm.nih.gov/pubmed/23529666 http://dx.doi.org/10.1007/s10295-013-1264-8 |
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