Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism

Dipeptidyl peptidases (DP) 8 and 9 are homologous, cytoplasmic N-terminal post-proline-cleaving enzymes that are anti-targets for the development of DP4 (DPPIV/CD26) inhibitors for treating type II diabetes. To date, DP8 and DP9 have been implicated in immune responses and cancer biology, but their...

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Detalles Bibliográficos
Autores principales: Wilson, Claire H., Indarto, Dono, Doucet, Alain, Pogson, Lisa D., Pitman, Melissa R., McNicholas, Kym, Menz, R. Ian, Overall, Christopher M., Abbott, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656252/
https://www.ncbi.nlm.nih.gov/pubmed/23519473
http://dx.doi.org/10.1074/jbc.M112.445841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656252/
https://www.ncbi.nlm.nih.gov/pubmed/23519473
http://dx.doi.org/10.1074/jbc.M112.445841

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