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Succinate Dehydrogenase Deficiency in Pediatric and Adult Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies targeted to these receptor tyrosine kinases comprise part of the treatment regimen for metastatic and inoperable GISTs. A minority (10–15%) of GISTs...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656383/ https://www.ncbi.nlm.nih.gov/pubmed/23730622 http://dx.doi.org/10.3389/fonc.2013.00117 |