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Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs
Mendelian disorders are often caused by mutations in genes that are not lethal but induce functional distortions leading to diseases. Here we study the extent of gene duplicates that might compensate genes causing monogenic diseases. We provide evidence for pervasive functional redundancy of human m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656685/ https://www.ncbi.nlm.nih.gov/pubmed/23696728 http://dx.doi.org/10.1371/journal.pcbi.1003073 |