A Salt Bridge in Intracellular Loop 2 Is Essential for Folding of Human P-Glycoprotein

[Image: see text] There is no high-resolution structure of the human P-glycoprotein (P-gp, ABCB1) drug pump. Homology models based on the crystal structures of mouse and Caenorhabditis elegans P-gps show extensive contacts between intracellular loop 2 (ICL2, in the first transmembrane domain) and th...

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Detalles Bibliográficos
Autores principales: Loo, Tip W., Clarke, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656768/
https://www.ncbi.nlm.nih.gov/pubmed/23634976
http://dx.doi.org/10.1021/bi400425k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656768/
https://www.ncbi.nlm.nih.gov/pubmed/23634976
http://dx.doi.org/10.1021/bi400425k

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