The Co-Repressor SMRT Delays DNA Damage-Induced Caspase Activation by Repressing Pro-Apoptotic Genes and Modulating the Dynamics of Checkpoint Kinase 2 Activation

Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle arrest and DNA repair or programmed cell death. Here, we report the identification of a new role of Chk2 in transcriptional regulation that also contributes to modulating...

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Detalles Bibliográficos
Autores principales: Scafoglio, Claudio, Smolka, Marcus, Zhou, Huilin, Perissi, Valentina, Rosenfeld, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656868/
https://www.ncbi.nlm.nih.gov/pubmed/23690919
http://dx.doi.org/10.1371/journal.pone.0059986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656868/
https://www.ncbi.nlm.nih.gov/pubmed/23690919
http://dx.doi.org/10.1371/journal.pone.0059986

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