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Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species

Mitochondria are known to be a major source and target of oxidative stress. Oxidative stress increases during aging and is suggested to underlie in part the aging process. We have previously documented an increase in endogenous caspase-2 (casp2) activity in hepatocytes obtained from old (28 months)...

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Detalles Bibliográficos
Autores principales: Lopez-Cruzan, Marisa, Herman, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657345/
https://www.ncbi.nlm.nih.gov/pubmed/23504374
http://dx.doi.org/10.1007/s10522-013-9415-x