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Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species
Mitochondria are known to be a major source and target of oxidative stress. Oxidative stress increases during aging and is suggested to underlie in part the aging process. We have previously documented an increase in endogenous caspase-2 (casp2) activity in hepatocytes obtained from old (28 months)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657345/ https://www.ncbi.nlm.nih.gov/pubmed/23504374 http://dx.doi.org/10.1007/s10522-013-9415-x |