Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity. Moreover, the level of Wnt signalling activi...

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Detalles Bibliográficos
Autores principales: Blauwkamp, Timothy A., Nigam, Shelly, Ardehali, Reza, Weissman, Irving L., Nusse, Roel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657997/
https://www.ncbi.nlm.nih.gov/pubmed/22990866
http://dx.doi.org/10.1038/ncomms2064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657997/
https://www.ncbi.nlm.nih.gov/pubmed/22990866
http://dx.doi.org/10.1038/ncomms2064

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