The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Seven transmembrane helical receptors (7TMRs) modulate cell function via different types of G proteins, often in a ligand-specific manner. Class A 7TMRs harbour allosteric vestibules in the entrance of their ligand-binding cavities, which are in the focus of current drug discovery. However, their bi...

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Detalles Bibliográficos
Autores principales: Bock, Andreas, Merten, Nicole, Schrage, Ramona, Dallanoce, Clelia, Bätz, Julia, Klöckner, Jessica, Schmitz, Jens, Matera, Carlo, Simon, Katharina, Kebig, Anna, Peters, Lucas, Müller, Anke, Schrobang-Ley, Jasmin, Tränkle, Christian, Hoffmann, Carsten, De Amici, Marco, Holzgrabe, Ulrike, Kostenis, Evi, Mohr, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658004/
https://www.ncbi.nlm.nih.gov/pubmed/22948826
http://dx.doi.org/10.1038/ncomms2028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658004/
https://www.ncbi.nlm.nih.gov/pubmed/22948826
http://dx.doi.org/10.1038/ncomms2028

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