Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab

BACKGROUND: Phosphatidylinositol 3-kinase (PI3K) pathway activation has been suggested to negatively influence response to anti-HER2 therapy in breast cancer patients. The present study focused on mutations of the PIK3CA gene, encoding one of the two PI3K subunits. METHODS: PIK3CA mutations were ass...

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Detalles Bibliográficos
Autores principales: Cizkova, M, Dujaric, M-E, Lehmann-Che, J, Scott, V, Tembo, O, Asselain, B, Pierga, J-Y, Marty, M, de Cremoux, P, Spyratos, F, Bieche, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658522/
https://www.ncbi.nlm.nih.gov/pubmed/23612454
http://dx.doi.org/10.1038/bjc.2013.164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658522/
https://www.ncbi.nlm.nih.gov/pubmed/23612454
http://dx.doi.org/10.1038/bjc.2013.164

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