Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells

Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7(DNp53)) were employed to investigate the relationship between induction of genoto...

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Detalles Bibliográficos
Autores principales: LEONTOVICH, ALEXEY A., SALISBURY, JEFFREY L., VEROUX, MASSIMILIANO, TALLARITA, TIZIANO, BILLADEAU, DANIEL, McCUBREY, JAMES, INGLE, JAMES, GALANIS, EVANTHIA, D’ASSORO, ANTONINO B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658847/
https://www.ncbi.nlm.nih.gov/pubmed/23446853
http://dx.doi.org/10.3892/or.2013.2313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658847/
https://www.ncbi.nlm.nih.gov/pubmed/23446853
http://dx.doi.org/10.3892/or.2013.2313

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