A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP(2)-Dependent Gating

In the absence of intracellular nucleotides, ATP-sensitive potassium (K(ATP)) channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisphosphate (PIP(2))-dependent gating process. Previous studies show that stability of this activity requires subunit-subunit interactions in the cytopl...

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Detalles Bibliográficos
Autores principales: Bushman, Jeremy D., Zhou, Qing, Shyng, Show-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659044/
https://www.ncbi.nlm.nih.gov/pubmed/23700433
http://dx.doi.org/10.1371/journal.pone.0063733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659044/
https://www.ncbi.nlm.nih.gov/pubmed/23700433
http://dx.doi.org/10.1371/journal.pone.0063733

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