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A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP(2)-Dependent Gating
In the absence of intracellular nucleotides, ATP-sensitive potassium (K(ATP)) channels exhibit spontaneous activity via a phosphatidylinositol-4,5-bisphosphate (PIP(2))-dependent gating process. Previous studies show that stability of this activity requires subunit-subunit interactions in the cytopl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659044/ https://www.ncbi.nlm.nih.gov/pubmed/23700433 http://dx.doi.org/10.1371/journal.pone.0063733 |