Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products

Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance t...

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Detalles Bibliográficos
Autores principales: Bohni, Nadine, Cordero-Maldonado, María Lorena, Maes, Jan, Siverio-Mota, Dany, Marcourt, Laurence, Munck, Sebastian, Kamuhabwa, Appolinary R., Moshi, Mainen J., Esguerra, Camila V., de Witte, Peter A. M., Crawford, Alexander D., Wolfender, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660303/
https://www.ncbi.nlm.nih.gov/pubmed/23700445
http://dx.doi.org/10.1371/journal.pone.0064006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660303/
https://www.ncbi.nlm.nih.gov/pubmed/23700445
http://dx.doi.org/10.1371/journal.pone.0064006

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