Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal cardiomyocyte growth, suggesting its involvement in endogenous mechanisms of myocardial histogenesis and regeneration. In the pres...

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Detalles Bibliográficos
Autores principales: Sassoli, Chiara, Chellini, Flaminia, Pini, Alessandro, Tani, Alessia, Nistri, Silvia, Nosi, Daniele, Zecchi-Orlandini, Sandra, Bani, Daniele, Formigli, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660557/
https://www.ncbi.nlm.nih.gov/pubmed/23704950
http://dx.doi.org/10.1371/journal.pone.0063896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660557/
https://www.ncbi.nlm.nih.gov/pubmed/23704950
http://dx.doi.org/10.1371/journal.pone.0063896

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