Cargando…

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal cardiomyocyte growth, suggesting its involvement in endogenous mechanisms of myocardial histogenesis and regeneration. In the pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sassoli, Chiara, Chellini, Flaminia, Pini, Alessandro, Tani, Alessia, Nistri, Silvia, Nosi, Daniele, Zecchi-Orlandini, Sandra, Bani, Daniele, Formigli, Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660557/ https://www.ncbi.nlm.nih.gov/pubmed/23704950 http://dx.doi.org/10.1371/journal.pone.0063896

Ejemplares similares

Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †
por: Chellini, Flaminia, et al.
Publicado: (2018)

Bone Marrow Mesenchymal Stromal Cells Stimulate Skeletal Myoblast Proliferation through the Paracrine Release of VEGF
por: Sassoli, Chiara, et al.
Publicado: (2012)

Red (635 nm), Near-Infrared (808 nm) and Violet-Blue (405 nm) Photobiomodulation Potentiality on Human Osteoblasts and Mesenchymal Stromal Cells: A Morphological and Molecular In Vitro Study
por: Tani, Alessia, et al.
Publicado: (2018)

Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration
por: Nistri, Silvia, et al.
Publicado: (2012)

Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling
por: Formigli, Lucia, et al.
Publicado: (2007)

Platelet-Rich Plasma Modulates Gap Junction Functionality and Connexin 43 and 26 Expression During TGF-β1–Induced Fibroblast to Myofibroblast Transition: Clues for Counteracting Fibrosis
por: Squecco, Roberta, et al.
Publicado: (2020)

Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration
por: Chellini, Flaminia, et al.
Publicado: (2019)

Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation
por: Sassoli, Chiara, et al.
Publicado: (2018)

Mesenchymal Stromal Cell Secreted Sphingosine 1-Phosphate (S1P) Exerts a Stimulatory Effect on Skeletal Myoblast Proliferation
por: Sassoli, Chiara, et al.
Publicado: (2014)

Functional and histopathological improvement of the post-infarcted rat heart upon myoblast cell grafting and relaxin therapy
por: Bonacchi, Massimo, et al.
Publicado: (2009)

Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration
por: Sassoli, Chiara, et al.
Publicado: (2012)

Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart
por: Nistri, Silvia, et al.
Publicado: (2017)

Bone Marrow-Mesenchymal Stromal Cell Secretome as Conditioned Medium Relieves Experimental Skeletal Muscle Damage Induced by Ex Vivo Eccentric Contraction
por: Squecco, Roberta, et al.
Publicado: (2021)

Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane
por: Fantappiè, Ornella, et al.
Publicado: (2015)

Morphological evidence for telocytes as stromal cells supporting satellite cell activation in eccentric contraction-induced skeletal muscle injury
por: Manetti, Mirko, et al.
Publicado: (2019)

Relaxin receptors and nitric oxide synthases: search for the missing link
por: Nistri, Silvia, et al.
Publicado: (2003)

Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction
por: Sassoli, Chiara, et al.
Publicado: (2011)

Correlation between Sialylation Status and Cell Susceptibility to Amyloid Toxicity
por: Sgambati, Eleonora, et al.
Publicado: (2022)

Protection from cigarette smoke‐induced vascular injury by recombinant human relaxin‐2 (serelaxin)
por: Pini, Alessandro, et al.
Publicado: (2016)

Porcine Relaxin but Not Serelaxin Shows Residual Bioactivity after In Vitro Simulated Intestinal Digestion—Clues for the Development of New Relaxin Peptide Agonists Suitable for Oral Delivery
por: Pacini, Lorenzo, et al.
Publicado: (2022)

Neuroinflammation: Integrated Nervous Tissue Response through Intercellular Interactions at the “Whole System” Scale
por: Nosi, Daniele, et al.
Publicado: (2021)

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
por: D'Ercole, Annunziata, et al.
Publicado: (2022)

Relaxin as a natural agent for vascular health
por: Bani, Daniele
Publicado: (2008)

Human Relaxin-2 (Serelaxin) Attenuates Oxidative Stress in Cardiac Muscle Cells Exposed In Vitro to Hypoxia–Reoxygenation. Evidence for the Involvement of Reduced Glutathione Up-Regulation
por: Nistri, Silvia, et al.
Publicado: (2020)

Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation
por: Garella, Rachele, et al.
Publicado: (2023)

Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats
por: Nistri, Silvia, et al.
Publicado: (2015)

Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
por: Collino, Massimo, et al.
Publicado: (2013)

Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration
por: Sassoli, Chiara, et al.
Publicado: (2019)

Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment
por: Wnuk, Dawid, et al.
Publicado: (2020)

Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway
por: Zhao, Bin, et al.
Publicado: (2017)

Hypoxia drives the transition of human dermal fibroblasts to a myofibroblast-like phenotype via the TGF-β1/Smad3 pathway
por: Zhao, Bin, et al.
Publicado: (2020)

Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
por: Xu, Ruohao, et al.
Publicado: (2023)

Sepsis induces albuminuria and alterations in the glomerular filtration barrier: a morphofunctional study in the rat
por: Adembri, Chiara, et al.
Publicado: (2011)

Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway
por: Zhou, Yan, et al.
Publicado: (2018)

Morphofunctional Investigation in a Transgenic Mouse Model of Alzheimer’s Disease: Non-Reactive Astrocytes Are Involved in Aβ Load and Reactive Astrocytes in Plaque Build-Up
por: Lana, Daniele, et al.
Publicado: (2023)

SMAD-Independent Down-Regulation of Caveolin-1 by TGF-β: Effects on Proliferation and Survival of Myofibroblasts
por: Sanders, Yan Y., et al.
Publicado: (2015)

Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition
por: Tang, Philip Chiu‐Tsun, et al.
Publicado: (2021)

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization
por: Paw, Milena, et al.
Publicado: (2018)

AB198. Estrogen attenuates the TGFβ1-induced conversion of primary penile tunica albuginea fibroblasts into myofibroblasts and inhibits collagen production and myofibroblast contraction by modulating the Smad and Rho/ROCK signaling pathways
por: Jiang, Hesong, et al.
Publicado: (2015)

Defining the Molecular Mechanisms of the Relaxant Action of Adiponectin on Murine Gastric Fundus Smooth Muscle: Potential Translational Perspectives on Eating Disorder Management
por: Garella, Rachele, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_09vl3avind4kh8319mjuvgj10p